Lenalidomide-13C5,15N is a variant of Lenalidomide labeled with 15N and 13C. Lenalidomide (CC-5013), a derivative of Thalidomide, is an orally active immunomodulatory agent acting as a molecular glue. It serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the selective ubiquitination and degradation of the lymphoid transcription factors IKZF1 and IKZF3 via the CRBN-CRL4 ubiquitin ligase. Notably, Lenalidomide (CC-5013) suppresses the growth of mature B cell lymphomas, including multiple myeloma, and stimulates T cells to release interleukin-2 (IL-2).
Target-Kategorie:
Molecular Glues|||Ligands for E3 Ligase|||Apoptosis
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
