Vardenafil-d5hydrochloride is the deuterium-labeled version of Vardenafil hydrochloride. Vardenafil dihydrochloride is a highly selective and orally active phosphodiesterase 5 (PDE5) inhibitor, with an IC50 of 0.7 nM. It displays IC50 values of 180 nM and 11 nM for PDE1 and PDE6, respectively, while for PDE3 and PDE4, the IC50 is greater than 1000 nM. This compound non-competitively inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP), leading to increased cGMP levels. Vardenafil dihydrochloride is useful for studying conditions such as erectile dysfunction, hepatitis, and diabetes.
Target-Kategorie:
Endogenous Metabolite|||PDE
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