Proguanil-D6 hydrochloride is a deuterated compound of Proguanil hydrochloride (T4382). Proguanil hydrochloride has a CAS number of 637-32-1. Proguanil Hydrochloride is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, proguanil is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite.
Molekulargewicht:
296.23
Formel:
C11H11D6Cl2N5
Target-Kategorie:
Parasite|||Antifolate
TMIH-0457
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