Catalyzes the irreversible cleavage of the glycosidic bond in both 5-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5-deoxyadenosine accumulation.
Molekulargewicht:
31.8 kDa (predicted)
TMPH-00692
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