SMURF2 Protein, Human, Recombinant (His)

Produktübersicht

• Artikelname: SMURF2 Protein, Human, Recombinant (His)
• Artikelnummer: TGM-TMPH-01269
• Hersteller Artikelnummer: TMPH-01269
• Alternativnummer: TGM-TMPH-01269-1MG,TGM-TMPH-01269-5UG,TGM-TMPH-01269-10UG,TGM-TMPH-01269-20UG,TGM-TMPH-01269-50UG,TGM-TMPH-01269-100UG,TGM-TMPH-01269-200UG,TGM-TMPH-01269-500UG
• Hersteller: TargetMol
• Kategorie: Biochemikalien
• Alternative Synonym: hSMURF2 , E3 ubiquitin-protein ligase SMURF2 , SMAD ubiquitination regulatory factor 2 , SMAD-specific E3 ubiquitin-protein ligase 2 , HECT-type E3 ubiquitin transferase SMURF2 , SMURF2

Produktbeschreibung

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby downregulating TGF-beta signaling. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with AIMP1. Also forms a stable complex with TGF-beta receptor-mediated phosphorylated SMAD1, SMAD2 and SMAD3, and targets SMAD1 and SMAD2 for ubiquitination and proteasome-mediated degradation. SMAD2 may recruit substrates, such as SNON, for ubiquitin-dependent degradation. Negatively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation., (Microbial infection) In case of filoviruses Ebola/EBOV and Marburg/MARV infection, the complex formed by viral matrix protein VP40 and SMURF2 facilitates virus budding.

Bilder

TMPH-01269