GBA Protein, Human, Recombinant

Produktübersicht

• Artikelname: GBA Protein, Human, Recombinant
• Artikelnummer: TGM-TMPH-01624
• Hersteller Artikelnummer: TMPH-01624
• Alternativnummer: TGM-TMPH-01624-1MG,TGM-TMPH-01624-5UG,TGM-TMPH-01624-10UG,TGM-TMPH-01624-20UG,TGM-TMPH-01624-50UG,TGM-TMPH-01624-100UG,TGM-TMPH-01624-200UG,TGM-TMPH-01624-500UG
• Hersteller: TargetMol
• Kategorie: Biochemikalien
• Alternative Synonym: Cholesterol glucosyltransferase (SGTase) , Glucosylceramidase beta 1 , Lysosomal acid glucosylceramidase , Lysosomal glycosylceramidase , Beta-glucosylceramidase 1 , Lysosomal acid GCase , GBA1 , Imiglucerase , Beta-glucocerebrosidase (Beta-GC) , GC , D-glucosyl-N-acylsphingosine glucohydrolase , Lysosomal cholesterol glycosyltransferase , GBA , Lysosomal galactosylceramidase , Acid beta-glucosidase , GLUC , Alglucerase , Cholesteryl-beta-glucosidase

Produktbeschreibung

Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. The short chain saturated C8:0-GlcCer and the mono-unsaturated C18:0-GlcCer being the most effective glucose donors for that transglucosylation reaction. Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl-beta-D-glucoside to ceramide. Finally, may also hydrolyze cholesteryl-beta-D-glucoside to produce D-glucose and cholesterol.

Bilder

TMPH-01624