PRAME Protein, Human, Recombinant (E. coli, His)

Produktübersicht

• Artikelname: PRAME Protein, Human, Recombinant (E. coli, His)
• Artikelnummer: TGM-TMPH-01650
• Hersteller Artikelnummer: TMPH-01650
• Alternativnummer: TGM-TMPH-01650-1MG,TGM-TMPH-01650-5UG,TGM-TMPH-01650-10UG,TGM-TMPH-01650-20UG,TGM-TMPH-01650-50UG,TGM-TMPH-01650-100UG,TGM-TMPH-01650-200UG,TGM-TMPH-01650-500UG
• Hersteller: TargetMol
• Kategorie: Biochemikalien
• Alternative Synonym: MAPE , Opa-interacting protein 4 (OIP-4) , OIP4 , Preferentially expressed antigen of melanoma , PRAME , Melanoma antigen preferentially expressed in tumors

Produktbeschreibung

Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation. The CRL2(PRAME) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding. In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role in chromstin regulation. Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG: prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.

Bilder

TMPH-01650