SMAD6 Protein, Human, Recombinant (E. coli, His & Myc)

Produktübersicht

• Artikelname: SMAD6 Protein, Human, Recombinant (E. coli, His & Myc)
• Artikelnummer: TGM-TMPH-01702
• Hersteller Artikelnummer: TMPH-01702
• Alternativnummer: TGM-TMPH-01702-1MG,TGM-TMPH-01702-5UG,TGM-TMPH-01702-10UG,TGM-TMPH-01702-20UG,TGM-TMPH-01702-50UG,TGM-TMPH-01702-100UG,TGM-TMPH-01702-200UG,TGM-TMPH-01702-500UG
• Hersteller: TargetMol
• Kategorie: Biochemikalien
• Alternative Synonym: Mothers against DPP homolog 6 , MAD homolog 6 , SMAD family member 6 (SMAD 6,Smad6,hSMAD6) , MADH6 , Mothers against decapentaplegic homolog 6 , SMAD6

Produktbeschreibung

Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I transforming growth factor-beta. Acts as a mediator of TGF-beta and BMP anti-inflammatory activities. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. Blocks the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.

Bilder

TMPH-01702