SKP2 Protein, Human, Recombinant (His & SUMO)

Produktübersicht

• Artikelname: SKP2 Protein, Human, Recombinant (His & SUMO)
• Artikelnummer: TGM-TMPH-02131
• Hersteller Artikelnummer: TMPH-02131
• Alternativnummer: TGM-TMPH-02131-1MG,TGM-TMPH-02131-5UG,TGM-TMPH-02131-10UG,TGM-TMPH-02131-20UG,TGM-TMPH-02131-50UG,TGM-TMPH-02131-100UG,TGM-TMPH-02131-200UG,TGM-TMPH-02131-500UG
• Hersteller: TargetMol
• Kategorie: Biochemikalien
• Alternative Synonym: F-box/LRR-repeat protein 1 , S-phase kinase-associated protein 2 , Cyclin-A/CDK2-associated protein p45 , FBXL1 , p45skp2 , SKP2 , F-box protein Skp2

Produktbeschreibung

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration., Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus.

Bilder

TMPH-02131