TRA-2 beta , Transformer-2 protein homolog beta , TRA2-beta , SFRS10 , Splicing factor, arginine/serine-rich 10 , hTRA2-beta , Transformer-2 protein homolog B , TRA2B
Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.
TMPH-02228
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