Cytotoxin 2 , Cardiotoxin 1A , Cardiotoxin 2 (CTX-2) , Cardiotoxin II , Cardiotoxin A2 (CTX A2) , Cardiotoxin analog II
Basic protein that binds to cell membrane and depolarizes cardiomyocytes. It also shows lytic activities, but 2-fold less important than that of CTX-A4. It binds to the integrin alpha-V/beta-3 (ITGAV/ITGB3) with a moderate affinity. It may interact with sulfatides in the cell membrane which induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It also may target the mitochondrial membrane and induce mitochondrial swelling and fragmentation.
TMPH-03036
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