GITR/TNFRSF18 Protein, Mouse, Recombinant (hFc & His)

Produktübersicht

• Artikelname: GITR/TNFRSF18 Protein, Mouse, Recombinant (hFc & His)
• Artikelnummer: TGM-TMPJ-00110
• Hersteller Artikelnummer: TMPJ-00110
• Alternativnummer: TGM-TMPJ-00110-1MG,TGM-TMPJ-00110-5UG,TGM-TMPJ-00110-10UG,TGM-TMPJ-00110-20UG,TGM-TMPJ-00110-50UG,TGM-TMPJ-00110-100UG,TGM-TMPJ-00110-200UG,TGM-TMPJ-00110-500UG
• Hersteller: TargetMol
• Kategorie: Biochemikalien
• Alternative Synonym: Tnfrsf18 , GITR-D , CD357 , AITR , Tumor necrosis factor receptor superfamily member 18 , Glucocorticoid-induced TNFR-related protein

Produktbeschreibung

Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA,isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6 and binds through its C-terminus to SIVA1/SIVA.It preferentially expressed in activated T lymphocytes and up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.

Produkteigenschaften

• Molekulargewicht: 60 KDa (reducing condition)

Bilder

TMPJ-00110