TIM-3/KIM-3/HAVCR2 Protein, Cynomolgus, Recombinant (His)

Produktübersicht

• Artikelname: TIM-3/KIM-3/HAVCR2 Protein, Cynomolgus, Recombinant (His)
• Artikelnummer: TGM-TMPJ-00189
• Hersteller Artikelnummer: TMPJ-00189
• Alternativnummer: TGM-TMPJ-00189-1MG, TGM-TMPJ-00189-5UG, TGM-TMPJ-00189-10UG, TGM-TMPJ-00189-20UG, TGM-TMPJ-00189-50UG, TGM-TMPJ-00189-100UG, TGM-TMPJ-00189-200UG, TGM-TMPJ-00189-500UG
• Hersteller: TargetMol
• Kategorie: Biochemikalien
• Alternative Synonym: HAVCR2 , Tim-3 , TIM3 , T cell immunoglobulin and mucin domain3

Produktbeschreibung

T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid (aa)extracellular domain (ECD), a 21 aa transmembrane segment, and a 78 aa cytoplasmic tail. TIM3 is up-regulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). Its binding to Galectin9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. TIM3 ligation attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. TIM3 interactions with Galectin-9 can trigger immune stimulatory effects, such as the coactivation of NK cell cytotoxicity.

Bilder

TMPJ-00189