DR6 Protein, Mouse, Recombinant (hFc & His)

Produktübersicht

• Artikelname: DR6 Protein, Mouse, Recombinant (hFc & His)
• Artikelnummer: TGM-TMPJ-00358
• Hersteller Artikelnummer: TMPJ-00358
• Alternativnummer: TGM-TMPJ-00358-1MG,TGM-TMPJ-00358-5UG,TGM-TMPJ-00358-10UG,TGM-TMPJ-00358-20UG,TGM-TMPJ-00358-50UG,TGM-TMPJ-00358-100UG,TGM-TMPJ-00358-200UG,TGM-TMPJ-00358-500UG
• Hersteller: TargetMol
• Kategorie: Biochemikalien
• Alternative Synonym: BM-018 , CD358 , DR6 , Tnfrsf21 , Tumor necrosis factor receptor superfamily member 21 , Death receptor 6

Produktbeschreibung

Tumor necrosis factor receptor superfamily member 21(DR6) is a single-pass type I membrane protein and contains 1 death domain and 4 TNFR-Cys repeats. The protein may activate NF-kappa-B and promote apoptosis and it may activate JNK and be involved in T-cell differentiation.It is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).

Bilder

TMPJ-00358