CTLA-4 Protein, Mouse, Recombinant (Flag)

Produktübersicht

• Artikelname: CTLA-4 Protein, Mouse, Recombinant (Flag)
• Artikelnummer: TGM-TMPJ-00420
• Hersteller Artikelnummer: TMPJ-00420
• Alternativnummer: TGM-TMPJ-00420-1MG,TGM-TMPJ-00420-10UG,TGM-TMPJ-00420-20UG,TGM-TMPJ-00420-50UG,TGM-TMPJ-00420-100UG,TGM-TMPJ-00420-200UG,TGM-TMPJ-00420-500UG
• Hersteller: TargetMol
• Kategorie: Biochemikalien
• Alternative Synonym: Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4, CD152, Ctla4

Produktbeschreibung

Mouse Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule. Within the ECD, Mouse CTLA-4 shares 68% aa sequence identity with human. CTLA4 is similar to the T cell costimulatory protein CD28 since both of the molecules bind to CD80 and CD86 on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found inregulatory T cells and may play an important role in their functions. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA4. Genetic variations of CTLA4 have been associated with susceptibility to systemic lupus erythematosus(SLE), Gravesdisease(GRD), Celiac disease type3(CELIAC3) and Hepatitis B virus infection(HBVinfection).

Bilder

TMPJ-00420