Suppressor of Cdc Thirteen Homolog , CST Complex Subunit STN1 , Oligonucleotide/Oligosaccharide-Binding Fold-Containing Protein 1 , OBFC1 , STN1
CST Complex Subunit STN1 (OBFC1) is a 368 amino acid protein that contains one OB DNA-binding domain. It is a member of the STN1 family. OBFC1 is component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.
TMPJ-00516
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