Siglec-7 Protein,Human,Recombinant (aa 19-353, His)

Produktübersicht

• Artikelname: Siglec-7 Protein,Human,Recombinant (aa 19-353, His)
• Artikelnummer: TGM-TMPJ-01397
• Hersteller Artikelnummer: TMPJ-01397
• Alternativnummer: TGM-TMPJ-01397-1MG, TGM-TMPJ-01397-5UG, TGM-TMPJ-01397-10UG, TGM-TMPJ-01397-20UG, TGM-TMPJ-01397-50UG, TGM-TMPJ-01397-100UG, TGM-TMPJ-01397-200UG, TGM-TMPJ-01397-500UG
• Hersteller: TargetMol
• Kategorie: Biochemikalien
• Alternative Synonym: AIRM1 , p75/AIRM1 , CD328 antigen , CD328 , AIRM-1 , siglec-7 , QA79 , p75 , sialic acid binding Ig-like lectin 7 , sialic acid-binding Ig-like lectin 7 , D-siglec , CDw328 , AIRM1QA79 membrane protein , Siglec7

Produktbeschreibung

Siglecs (sialic acid binding Ig-like lectins) are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains. Eleven human Siglecs have been cloned and characterized. Human Siglec-7 encodes a 467 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-terminal Ig-like V-type domain, two Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail. Siglec-7 exists as a monomer on the cell surface and is expressed on natural killer cells, CD8+ T cells and monocytes. It binds equally well to both alpha 2,3- and alpha 2,6-linked sialic acid. The gene encoding Siglec-7 was mapped to chromosome 19q13.3.