Notch 2 Protein, Human, Recombinant (His & Avi), Biotinylated

Produktübersicht

• Artikelname: Notch 2 Protein, Human, Recombinant (His & Avi), Biotinylated
• Artikelnummer: TGM-TMPK-00466
• Hersteller Artikelnummer: TMPK-00466
• Alternativnummer: TGM-TMPK-00466-5UG,TGM-TMPK-00466-10UG,TGM-TMPK-00466-20UG,TGM-TMPK-00466-50UG,TGM-TMPK-00466-100UG,TGM-TMPK-00466-200UG,TGM-TMPK-00466-500UG
• Hersteller: TargetMol
• Kategorie: Biochemikalien
• Alternative Synonym: AGS2 , NOTCH2 , N2 , N2ECD , Notch-2 , HJCYS

Produktbeschreibung

Human Notch-2 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes. Although Notch proteins are structurally and functionally similar, deletion of either Notch-1 or Notch-2 is lethal, showing that not all functions overlap.Notch-2 functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.

Bilder

TMPK-00466