Signal regulatory protein alpha (SIRPalpha) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPalpha acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the don´t eat me signal.Cancer cells highly expressed CD47 that activate SIRP alpha and inhibit macrophage-mediated destruction. SIRP alpha V3 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 39.8 kDa and the accession number is ATD50864.1.
Molekulargewicht:
39.8 kDa (predicted). Due to glycosylation, the protein migrates to 50-70 kDa based on Tris-Bis PAGE result.
TMPK-00625
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