IgG1 is most abundant in serum among the four IgG subclasses (IgG1, 2, 3 and 4) and binds to Fc receptors (FcgammaR) on phagocytic cells with high affinity. Fc fragment is demonstrated to mediate phagocytosis, trigger inflammation, and target Ig to particular tissues.IgG1 Fc was reported has a novel role as a potential anti-inflammatory drug for treatment of human autoimmune diseases.
Molekulargewicht:
25.5 kDa (predicted). Due to glycosylation, the protein migrates to 31-33 kDa based on Tris-Bis PAGE result.
Reinheit:
>95%
TMPK-00759
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