ERAP2 Protein, Human, Recombinant (His)

Produktübersicht

• Artikelname: ERAP2 Protein, Human, Recombinant (His)
• Artikelnummer: TGM-TMPY-00992
• Hersteller Artikelnummer: TMPY-00992
• Alternativnummer: TGM-TMPY-00992-5UG,TGM-TMPY-00992-10UG,TGM-TMPY-00992-20UG,TGM-TMPY-00992-50UG
• Hersteller: TargetMol
• Kategorie: Biochemikalien
• Alternative Synonym: LRAP , FLJ23807 , FLJ23701 , L-RAP , endoplasmic reticulum aminopeptidase 2 , FLJ23633 , LRAP.ERAP2

Produktbeschreibung

Leukocyte-derived arginine aminopeptidase (LRAP), also known as endoplasmic reticulum-aminopeptidase 2 (ERAP2), is the second identified aminopeptidase localized in the in the lumenal side of endoplasmic reticulum (ER) processing antigenic peptides presented to major histocompatibility complex (MHC) class I molecules. It is a 96-amino acid protein with significant homology to placental leucine aminopeptidase and adipocyte-derived leucine aminopeptidase. LRAP preferentially hydrolyzes the basic residues Arg and Lys, and contains the HEXXH(X)18E zinc-binding motif, which is the characteristic of the M1 family of zinc metallopeptidases which also includes PILS/ARTS1/ERAP1 and LNPEP/PLAP. Induced by interferon-gamma, LRAP is able to trim various MHC class I antigenic peptide precursors.

Produkteigenschaften

• Molekulargewicht: 106 kDa (predicted), 115-125 kDa (reducing condition, due to glycosylation)

Bilder

TMPY-00992