Von Willebrand Factor (VWF) is a multimeric glycoprotein involved in hemostasis in blood, binds receptors on the surface of platelets and in connective tissue, thereby mediating the adhesion of platelets to sites of vascular injury. From studies it appears that VWF protein uncoils under these circumstances, decelerating passing platelets. VWF protein is deficient or defective in von Willebrand disease (VWD) and is involved in a large number of other diseases, including thrombosis, thrombotic thrombocytopenic purpura, Stroke, Heydes syndrome, possibly hemolytic-uremic syndrome and so on.
Molekulargewicht:
308 kDa (predicted), 260 and 350 kDa (reducing condition, due to glycosylation)
Reinheit:
0.872
TMPY-01075
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