SIRP beta 1 Protein, Mouse, Recombinant (His)

Produktübersicht

• Artikelname: SIRP beta 1 Protein, Mouse, Recombinant (His)
• Artikelnummer: TGM-TMPY-02388
• Hersteller Artikelnummer: TMPY-02388
• Alternativnummer: TGM-TMPY-02388-5UG, TGM-TMPY-02388-10UG, TGM-TMPY-02388-20UG, TGM-TMPY-02388-50UG
• Hersteller: TargetMol
• Kategorie: Biochemikalien
• Alternative Synonym: SIRP-beta , SIRP-beta , 99327N5Rik , Sirpb , Sirpb1 , Sirpb1a , SIRP-beta/Sirpb1a

Produktbeschreibung

SIRPB1A (Signal-regulatory protein beta 1A), also known as SIRP beta 1, belongs to signal-regulatory-protein (SIRP) family, and immunoglobulin superfamily. Signal-regulatory proteins (SIRPs) are cell-surface glycoproteins expressed on myeloid and neural cells that have been shown to recruit SH2 domain-containing protein phosphatase 1 (SHP-1) and SHP-2 and to regulate receptor tyrosine kinase-coupled signaling. SIRP are classified as SIRP alpha molecules, containing 11- to 113-amino acid long, or SIRP beta molecules, with a 5-amino acid long intracytoplasmic domain. SIRP beta 1 is a new DAP12-associated receptor involved in the activation of myeloid cells, which contains a short cytoplasmic domain that lacks sequence motifs capable of recruiting SHP-1 and SHP-2. SIRP beta 1 acts as an activating isoform of SIRP alpha molecules, confirming the co-existence of inhibitory ITIM-bearing molecules, recruiting SHP-1 and SHP-2 protein tyrosine phosphatases, and activating counterparts, whose engagement couples to protein tyrosine kinases via ITAM-bearing molecules.s