2-Hydroxychalcone is a drug synthesis intermediate for the synthesis of flavonoids. 2-Hydroxychalcone loaded in nanoemulsion showed fungicidal activity against Coccidioides parapsilosis in Danio rerio model.2-Hydroxychalcone induced cytotoxicity through oxidative stress in lipid-loaded Hepg2 cells.2-Hydroxychalcone inhibited the induction of ICAM-1, VCAM-alpha, tumor necrosis factor-alpha, and tumor necrosis factor-alpha as determined by reverse transcription-polymerase chain reaction determined by tumor necrosis factor-alpha induces steady-state transcript levels of ICAM-1, VCAM-1, and E-selectin, and therefore may interfere with the transcription of their genes.
