6-Dehydrogingerdione, CAS [[76060-35-0]]

Produktübersicht

• Artikelname: 6-Dehydrogingerdione, CAS [[76060-35-0]]
• Artikelnummer: TGM-TN1171
• Hersteller Artikelnummer: TN1171
• Alternativnummer: TGM-TN1171-1MG, TGM-TN1171-5MG, TGM-TN1171-10MG, TGM-TN1171-25MG, TGM-TN1171-50MG, TGM-TN1171-100MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien
• Alternative Synonym: 1-Dehydro-6-gingerdione

Produktbeschreibung

6-Dehydrogingerdione sensitizes human hepatoblastoma Hep G2 cells to TRAIL-induced apoptosis via a reactive oxygen species-mediated mechanism that enhances DR5 expression, up-regulates Ser-15 phosphorylation, and triggers nuclear translocation of p53. Abrogation of p53 using small interfering RNA markedly reduces 6-Dehydrogingerdione-induced DR5 and diminishes TRAIL responsiveness. ROS generation accompanies DR5 activation, and pretreatment with N-acetyl-L-cysteine significantly attenuates these apoptotic responses, confirming 6-Dehydrogingerdione acts through p53-dependent and oxidative stress-mediated apoptotic pathways.

Produkteigenschaften

• Molekulargewicht: 290.35
• Reinheit: 96.98%
• CAS Nummer: [76060-35-0]
• Formel: C17H22O4
• Target-Kategorie: TNF|||Apoptosis

Bilder

TN1171