Selaginellin has a neuroprotective effect against L-glutamate-induced neurotoxicity through mechanisms related to anti-oxidation and anti-apoptosis via scavenging reactive oxygen species and up-regulating the expression of klotho gene. Selaginellin shows inhibitory effect on high glucose-induced cell injury and apoptosis in differentiated PC12 cells, which is related to inhibition of LOX-1/NADPH oxidase-reactive oxygen species/caspase-3 signaling pathway.
Molekulargewicht:
512.55
CAS Nummer:
[941269-84-7]
Formel:
C34H24O5
Target-Kategorie:
Sirtuin|||Reactive Oxygen Species
TN6515
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