Heronamide C, a polyketide macrolactam antifungal agent synthesized by marine Actinomycetes, exhibits selective toxicity by inhibiting growth and promoting abnormal cell wall material accumulation in wild-type fission yeast cells (MIC = 0.13-0.28 µM), without affecting Gram-positive bacteria or human cancer cell lines, HeLa and MDA-MB-231. At 20 µM, it triggers reversible morphological alterations, notably the development of large intracellular structures, in HeLa cells.
Molekulargewicht:
449.635
CAS Nummer:
[1257083-94-5]
Formel:
C29H39NO3
Target-Kategorie:
Others
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