Jagged-1 (188-204)is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epidermal maturation. Exposing submerged keratinocytes monolayers to JAG-1 with elevated calcium concentration produces stratification with loricrin expression and NF-alphaB activation.
Molekulargewicht:
2107.4
CAS Nummer:
[219127-21-6]
Formel:
C93H127N25O26S3
Target-Kategorie:
Gamma-secretase
TP1540
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