Cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site, produces CaM-dependent activation of phosphodiesterase. Also binds to cytoplasmic sites on other Ca2+ channels, including NMDA and HIV-1 gp120-activated channels, inhibiting Ca2+-mediated cytotoxicity and apoptosis (IC50 = 52 µM). Shown to protect pancreatic acinar cells from gossypol induced necrosis. Inhibits VLA-5-mediated adhesion of mast cells to fibronectin in vitro and attenuates inflammatory cell influx in guinea pig lung in vivo.
Molekulargewicht:
842.09
CAS Nummer:
[145224-99-3]
Formel:
C40H75N9O10
Target-Kategorie:
PDE|||CaMK|||Apoptosis|||GluR
TP1910
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