Novel, cell-permeable inhibitor of protein kinase Mzeta (PKMzeta), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMzeta-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 µM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.
Molekulargewicht:
1928.4
CAS Nummer:
[863987-12-6]
Formel:
C90H154N30O17
Target-Kategorie:
PKC
TP1924
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