Cell-permeable peptide cleaved from protease-activated receptor 1 (PAR1) upon receptor activation. Attenuates endothelial cell migration and proliferation (IC50 ~ 3 µM), and induces cell cycle arrest. Promotes activation of caspase-3 and exhibits pro-apoptotic activity in vitro. Inhibits angiogenesis and exhibits cardioprotective activity in vivo.
Molekulargewicht:
4467.29
CAS Nummer:
[1065755-99-8]
Formel:
C191H330N64O53S3
Target-Kategorie:
Protease-activated Receptor
TP1965
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