Amyloid precursor c-terminal peptide has the amino acid sequence Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn. APP is best known as the precursor molecule whose proteolysis generates beta-amyloid (Abeta), a 37 to 49 amino acid peptide whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimers disease patients. So it is a possible contributor to Alzheimer's pathogenesis through MAPKs- and NF-kappaB-dependent astrocytosis.
Molekulargewicht:
1896.04
Formel:
C86H118N20O27S1
Target-Kategorie:
Others
TP2177
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