Pep1-DNP conjugate 9 is a functionalized peptide composed of a DNP-hapten and an FGFR1-binding peptide. It exhibits good affinity for FGFR1, with a dissociation constant (KD) of 5.01 µM. This compound effectively recruits anti-DNP antibodies to the surface of FGFR1-positive cells, inhibits FGF2-induced proliferation of rat skeletal myoblasts, and induces apoptosis. In mouse models, Pep1-DNP conjugate 9 demonstrates antitumor activity.
Molekulargewicht:
3004.31
Formel:
C135H207N37O41
Target-Kategorie:
FGFR|||Apoptosis
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
