Cyclo CRLLIF serves as a dual inhibitor of hypoxia-inducible factors HIF1 and HIF2, disrupting the interaction between HIF1-alpha and HIF2-alpha with HIF1-beta. It exhibits dissociation constants (KD) of 14.5 µM for HIF1-alpha and 10.2 µM for HIF2-alpha within the PAS-B domains.
Formel:
C36H59N9O6S
Target-Kategorie:
HIF/HIF Prolyl-Hydroxylase
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