IS4 is a selective competitive antagonist of CXCR4, exhibiting an IC50 of 0.65 nM in THP-1 cells and 38.75 nM in Jurkat cells. It remains stable in serum and is non-cytotoxic. IS4 competes with CXCL12 for binding to CXCR4, thereby inhibiting CXCL12-induced intracellular Ca2+ release and cancer cell migration. This compound is applicable in research on the prevention of metastasis in conditions such as breast cancer, prostate cancer, and leukemia.
Molekulargewicht:
1075.22
CAS Nummer:
[3067986-23-3]
Formel:
C48H62N14O11S2
Target-Kategorie:
CXCR
TP3721
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
