WLBU2 is an engineered cationic antimicrobial peptide (eCAP) designed to overcome the sensitivity issues of natural antimicrobial peptides (AMPs) in various environments. WLBU2 exhibits rapid bactericidal activity and has a minimum inhibitory concentration (MIC) value of 10 µM against numerous Gram-positive and Gram-negative bacteria, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococci, Klebsiella pneumoniae, Enterobacter aerogenes, Enterobacter cloacae, and Escherichia coli. It effectively prevents biofilm formation by Pseudomonas aeruginosa and retains its activity in mucus-rich, low pH, and high salt conditions, without adverse effects on human respiratory epithelial cells. Additionally, WLBU2 is applicable for studying cystic fibrosis (CF) and Pseudomonas aeruginosa infections.
Molekulargewicht:
3400.11
CAS Nummer:
[847061-43-2]
Formel:
C151H260N66O25
Target-Kategorie:
Antibacterial
TP3849
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