Caloxin 1b3 is a peptide and a selective inhibitor of the plasma membrane calcium pump 1 (PMCA1). It demonstrates a stronger inhibitory effect on the Ca2+-Mg2+-ATPase activity of PMCA1 in rabbit duodenal mucosa compared to PMCA4 in human erythrocyte ghosts. Additionally, Caloxin 1b3 increases cytoplasmic Ca2+ levels in endothelial cells and is useful in cardiovascular disease research.
Target-Kategorie:
Calcium Channel
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