DPMI-omega is a dual-specific D-peptide antagonist of the carcinogenic proteins MDM2 and MDMX. When loaded onto gold nanoparticles, DPMI-omega effectively penetrates tumor cells and kills them by reactivating the p53 signaling pathway. It disrupts the p53-MDM2/MDMX complex and inhibits the growth of B16 melanoma while inducing G0/G1 phase cell cycle arrest. Combined with anti-PD1 antibodies, DPMI-omega enhances immunotherapy by amplifying CD3+/CD8+ cytotoxic T cells and inhibiting CD4+/CD25+ regulatory T cells. DPMI-omega is applicable in melanoma research.
Target-Kategorie:
MDM-2/p53
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