Endo SH is a fusion protein of Endo S (derived from Streptococcus pyogenes) and Endo H (derived from Streptomyces plicatus), expressed in Escherichia coli. It cleaves the core structure of high-mannose, complex, and certain hybrid N-glycans in N-glycoproteins, effectively removing N-linked high-mannose glycans, and serves as a complete substitute for Endo S and Endo H.
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