Inosine-5-diphosphoric acid disodium salt, as a decoy substrate for NM23-H2, exhibits excellent binding ability at the GDP-binding site of NM23-H2 with a dissociation constant (KD) of 5.0 µM. It can inhibit c-MYC transcription by disrupting the interaction between NM23-H2-Pu27-GQ, thereby inducing apoptosis and G2/M cell cycle arrest without affecting the kinase activity mediated by NM23-H2. Inosine-5-diphosphoric acid disodium salt also possesses anti-hypoxic, antihypertensive, and antiarrhythmic activities, protects organisms from gamma-radiation damage, and can be used in research on cancers such as Burkitt lymphoma and cardiovascular diseases.
Molekulargewicht:
472.15
Reinheit:
99.93%
CAS Nummer:
[54735-61-4]
Formel:
C10H12N4Na2O11P2
Target-Kategorie:
c-Myc|||Apoptosis
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