5-(E)-VPG Phosphoramidite (5(E)-VP-2-OMe-iBu-GPhosphoramidite) is a structurally modified phosphoramidite reagent designed for synthesizing biologically stable oligonucleotides. It includes a VP protecting group that facilitates 5 end coupling with target oligonucleotide chains via solid-phase synthesis. The construction of the modified oligonucleotide is completed through oxidation and deprotection steps. This compound is particularly useful in RNAi and viral replication research.
