C14-490 is an ionizable cationic lipid (pKa= 5.94) utilized in the synthesis of lipid nanoparticles (LNPs). These LNPs serve as a platform for subsequent gene editing studies in hematopoietic stem cells (HSCs) in utero. C14-490 LNPs encapsulate SpCas9 mRNA and TTR sgRNA, employing an optimized B5 formulation parameter, and are further enhanced by the surface attachment of CD45 antibody F(ab)2 fragments to create Systemically Targeted Editing Mechanism LNPs (STEM LNPs).
Molekulargewicht:
1393.35
CAS Nummer:
[2639634-82-3]
Formel:
C86H177N5O7
Target-Kategorie:
Liposome
TYD-01884
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