SKLB-0124 is a potent degrader of PRMT6, exhibiting DC50 values of 15.4 µM in HCC827 cells and 16.4 µM in MDA-MB-435 cells. It does not degrade PRMT1 or PRMT8. SKLB-0124 has an IC50 value of 1.6 µM for PRMT6. It induces proteasome-dependent degradation of PRMT6 and significantly inhibits cell proliferation. Additionally, SKLB-0124 effectively induces apoptosis and cell cycle arrest, making it suitable for research in lung cancer and breast cancer.
Molekulargewicht:
531.75
CAS Nummer:
[3065966-31-3]
Formel:
C32H45N5O2
Target-Kategorie:
Apoptosis|||Histone Methyltransferase
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