ML323

Produktübersicht

• Artikelname: ML323
• Artikelnummer: UBP-F4120
• Hersteller Artikelnummer: F4120
• Alternativnummer: UBP-F4120-5
• Hersteller: UBPBio, LLC
• Kategorie: Sonstiges

Produktbeschreibung

ML323 is a cell permealbe, selective and highly potent inhibitor of USP1-UAF1 with IC50 of 76 nM in a Ub-Rho assay and 174 nM and 820 nM in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) and monoubiquitinated PCNA (Ub-PCNA) as substrates, respectively. ML 323 effectively sensitized cisplatin-resistant NSCLC H596 cells and U2OS osteosarcoma cells to cisplatin since it simultaneously targets two major DNA damage response pathways (TLS and FA) by inhibiting USP1-UAF1. ML323 was used at 10-30 µM in various in vitro assay.

Produkteigenschaften

• Molekulargewicht: 384.48 g/mol
• NCBI: 1572414
• Puffer: Powder, no buffer
• Quelle: chemical synthesis