OTUB1

Produktübersicht

• Artikelname: OTUB1
• Artikelnummer: UBP-H3000
• Hersteller Artikelnummer: H3000
• Alternativnummer: UBP-H3000-25
• Hersteller: UBPBio, LLC
• Kategorie: Sonstiges
• Spezies Reaktivität: Human

Produktbeschreibung

Deubiquitinating enzymes (DUBs) are proteases that posses the ability to cleave ubiquitin chains or the isopeptide bond that conjugates ubiquitin with a substrate. Human cells have approximately 100 DUBs that play important roles in regulating various cellular events. OTUB1 is a member of the ovarian tumor domain family. It is recognized as a K48 ubiquitin chain-specific DUB and can inhibit E2 enzymes, especially Ubc13 (also known as Ube2N), which is known to synthesize K63-linked ubiquitin chains. OTUB1 may also deubiquitinate TRAF3 and -6. This would negatively regulate virus-triggered type I IFN induction.

Produkteigenschaften

• Molekulargewicht: 31.2 kDa
• NCBI: 017670
• Puffer: 20 mM Tris, 150 mM NaCl, 2 mM BME, 10% Glycerol
• Quelle: E. coli recombinant