Rpn11 is a subunit of the 19S regulatory particle (PA700). It is a metalloprotease that catalyzes en bloc deubiquitination to remove a whole polyub chain from a substrate protein. The 26S proteaosme is composed of 33 different proteins and responsible for degrading polyubiquitinated proteins in a ATP hydrolysis-dependent manner. The 19S regulatory particle can bind polyubiqutin chains to recruit substrates, deubiquitinate to recycle ubiquitin, unfold substrate proteins under ATP hydrolysis, and translocate unfolded proteins to the 20S proteasome for hydrolysis.
Molekulargewicht:
IgG
Puffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Quelle:
Rabbit
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