| Benzo[a]pyrene diol epoxide stimulates an inflammatory response in normal human lung fibroblasts through a p53 and JNK mediated pathway. Benzo [a]pyrene diol epoxide (BPDE), a carcinogen present in tobacco smoke as well as in environmental pollution, induces esophageal carcinogenesis. Synonyms: (7R,8S,8aS,9aR)-rel-7,8,8a,9a-Tetrahydrobenzo[10,11]chryseno[3,4-b]oxirene-7,8-diol, (7alpha,8beta,8aalpha,9aalpha)-7,8,8a,9a-Tetrahydrobenzo[10,11]chryseno[3,4-b]oxirene-7,8-diol, ()-7alpha,8beta-Dihydroxy-9beta,10beta-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene, ()-7beta,8alpha-Dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene, ()-anti-BPDE, anti-Benzo[a]pyrene-7,8-diol-9,10-epoxide, trans-7,8-Dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene CAS Number: 58917-67-2 Molecular Weight: 302.32 Molecular Formula: C20H14O3 Purity: 95% Appearance: Pale yellow to yellow solid Melting Point: 164-166C Solubility: DMSO (Slightly) Method for Determining Identity: Proton NMR (DMSO-d6) Spectroscopic and Mass Spectrometric Analysis TLC Conditions: C18: Isopropanol: ammonium = 9.5:0.5. Visualized with UV and AMCS, Single spot, Rf=0.65 Storage and Stability: Powder is stable for 6 months after receipt at 4C. Hygroscopic. Under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap. |
