Bosutinib is a safe oral medicine with good bioavailability. It is effective for treating chronic myeloid leukemia (CML). It is also a potent ATP-competitive inhibitor for Src tyrosine kinase. Bosutinib inhibits epidermal growth factor receptor (EGFR). It suppresses solid tumors associated with breast, pancreas and prostate. Synonyms: SKI-606, 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile, WAY-173606 CAS No: 380843-75-4 Molecular Formula: C26H29Cl2N5O3 Molecular Weight: 530.45 Appearance: Off-white to light brown powder Purity: 98% (HPLC) Melting Point: 131-134C Solubility: DMF: 20mg/ml, DMSO: 20mg/ml, Ethanol: 20mg/ml, PBS (pH 7.2): 1mg/ml Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
530.45
Reinheit:
98% (HPLC)
Formulierung:
Off-white to light brown powder
CAS Nummer:
[380843-75-4]
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