25-Hydroxyvitamin D3 3-Sulfate is a metabolite of 24,25-Dihydroxyvitamin D3 and 25-Hydroxyvitamin D3. Calcifediol (INN), also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D (abbreviated 25(OH)D), is a prehormone that is produced in the liver by hydroxylation of vitamin D3 (cholecalciferol) by the enzyme cholecalciferol 25-hydroxylase which was isolated by Michael F. Holick. Physicians worldwide measure this metabolite to determine a patients vitamin D status. At a typical daily intake of vitamin D3, its full conversion to calcifediol takes approximately 7 days. Calcifediol is then converted in the kidneys (by the enzyme 25(OH)D-1alpha-hydroxylase) into calcitriol (1,25-(OH)2D3), a secosteroid hormone that is the active form of vitamin D. It can also be converted into 24-hydroxycalcidiol in the kidneys via 24-hydroxylation. Synonyms: (3beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-3,25-diol 3-(Hydrogen Sulfate) Sodium Salt, 25-Hydroxyvitamin D3 3-Sulfate Sodium Salt, 25-Hydroxyvitamin D3 3beta-Sulfate Sodium Salt, Calcifediol 3-Sulfate Sodium Salt CAS No: Free acid: 99447-30-0 Molecular Formula: C27H43NaO5S Molecular Weight: 502.68 Purity: 90% Appearance: Pale yellow to beige solid Solubility: Methanol (Slightly), Water (Slightly) Method for Determining identity: Proton NMR Spectroscopic and Mass Spectrometric Analysis Melting Point: 104-108C (dec.) (lit) Atmosphere: Inert Gas Storage and Stability: Long-term storage is recommended at -70C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Hygroscopic, Light sensitive and temperature sensitive. Store under inert atmophere.
Molekulargewicht:
502.68
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