2-O-Methylguanosine is a nucleoside that contains a 2-O-methyl group at the 2 position of the ribose. It is a component of many nucleic acids and is usually found as a minor component in RNA. 2-O-Methylguanosine has been shown to be an inhibitor of DNA polymerase and an activator of RNA polymerase, which may be due to its ability to form hydrogen bonds with the phosphate backbone. This compound has also been shown to act as a competitive inhibitor for both wild-type and mutant bacterial strains, suggesting that it can inhibit DNA synthesis in bacteria by binding to the enzymes active site. 2-O-Methylguanosine is present in relatively high concentrations in tissues, such as liver and muscle, where it is involved in metabolism or energy production. The optimum concentration for detection by analytical methods varies depending on the type of detector used. Synonyms: O2-Methylguanosine, 2-OMe-Guanosine, 2-OMe-G, 2-amino-9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-6,9-dihydro-3H-purin-6-one CAS No: 2140-71-8 Molecular Formula: C11H15N5O5 Molecular Weight: 297.27 Appearance: White solid Purity: 98% Melting Point: 227-231C (dec.) Solubility: DMSO: 100mg/ml, ultrasonic, Methanol Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at 4C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
297.27
Reinheit:
98%
Formulierung:
White solid
CAS Nummer:
[2140-71-8]
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